Which charms should I run in Hollow Knight?

depends where you are. once you know the map, wayward compass is wasted notches, swap it for quick slash or longnail. unbreakable strength is the best all-rounder if you can get it, or run the fragile one and just don't die. if you like spells, shaman stone with spell twister makes the screams your main damage. for the hard bosses most people end up on some mix of strength, quick slash and mark of pride.