Tips for surviving longer in Dandy's World?

Pick your toon for how you actually play. If you keep getting caught mid-run, a higher stealth toon lets you get away with a lot more. And spend your ichor on trinkets that suit that toon, they make a bigger difference early than people expect.

biggest thing is not doing machines alone once you get a few floors in. stick with at least one other person so someone can pull the twisted off you while the other finishes. also learn which twisteds are slow and which are fast. some you can just walk away from, the fast ones you have to break line of sight on. and use your items, people go down holding bandages all the time.